The biopatch has a special internal structure containing synthetically created plasmids (DNA molecules) encoded by the PDGF-B growth factor gene. When neighboring cells enter the patch, the process of bone regeneration begins.
“When cells enter the biopatch, they encounter plasmids and receive instructions from them. After that, the cells begin to produce PDGF-B, which enhances bone regeneration.” says Professor Aliasger Salem.
In laboratory tests, biopatches were implanted into a 5 x 2 mm hole in the skull of a test animal. Four weeks later, the result was compared with experiments where patches without plasmids were used, or no action was taken at all: a biopatch with plasmids showed a tenfold more effective level of bone regeneration.