For migraine sufferers, there is new hope for a cure as a new discovery promises new possibilities.
Migraine and glucose-related features (insulin deficiency or excess and type 2 diabetes) are widely recognized as common comorbidities, but scientists now have a specific genetic link that could lead to the development of a new field of therapy for debilitating disorders.
Researchers at the Queensland University of Technology in Australia have uncovered the culprit behind the gene correlations that cause so many migraine and headache sufferers to also struggle with glycemic diseases, which deal a double whammy to health problems. It is estimated that migraines affect more than 10% of the world’s population and are about three times more common in women, affecting more than 17 % .
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“Back in 1935, migraine was described as a ‘glycemic headache,'” said Dale Nyholt, professor at the Center for Genomics and Personalized Health (CHP). “Glycemic features such as insulin resistance, hyperinsulinemia (excess insulin), hypoglycemia (low in the blood) and type 2 diabetes are associated with migraine and headache.
The findings come after researchers analyzed the genomes of thousands of migraine patients to see if any genetic links could be identified. They performed cross-feature analysis to identify common genomic regions, loci, genes, and pathways, and then tested for random relationships.
“Of the nine glycemic characteristics we looked at, we found a significant genetic correlation between fasting insulin score (blood insulin levels) and glycated hemoglobin with both migraine and headache, while 2-hour glucose was only genetically associated with migraine ,” said Rafikul Islam, a CGP graduate student. “We also found regions containing genetic risk factors common to migraine and fasting insulin, fasting glucose, and glycated hemoglobin, and for headache, regions common to glucose, fasting insulin, glycated hemoglobin, and proinsulin. on an empty stomach”.
The genetic match is a significant step forward in our understanding of how migraine and associated glycemic symptoms manifest, and opens up exciting new possibilities for medical intervention.
“By identifying genetic correlations, common loci and genes in our analysis, we established a causal relationship and thus confirmed and improved our understanding of the relationship between migraine headache and glycemic characteristics,” said Nieholt.
This improved understanding will be welcome news for the millions of people around the world who are dealing with these serious health problems.
“Our results provide opportunities for developing new strategies for treating glycemic indexes in patients with migraine and headache, in particular increasing fasting proinsulin levels to protect against headache,” Islam added.
Focus has previously written about why touching a sore part of the body makes you feel better . Researchers are studying the neurons needed to relieve pain when touched. Pain-responsive cells in the brain are thought to calm down when these neurons receive sensory stimulation.