Perm scientists have developed a mathematical model for predicting complications in diabetes

Scientists have developed a mathematical model of microcirculation in the body of patients with diabetes mellitus. The developers believe that it will allow predicting the dangerous consequences of the disease and improve diagnosis.

Biomechanics of the Perm National Research Polytechnic University have developed a mathematical model of microcirculation in the body of patients with diabetes mellitus. The results of the study were published in the Russian Journal of Biomechanics.

The model made it possible to describe the biomechanical effects that occur in capillaries at the micro level. To “recreate” diabetic conditions, scientists have set a larger capillary radius, increased distance in it and increased hydraulic conductivity of the wall. They analyzed various microcirculation parameters: capillary radius and length, hydrostatic pressure at its arterial and venous ends, oncotic pressure, blood viscosity, hydraulic conductivity of the capillary wall, as well as hydraulic conductivity and tissue porosity. This made it possible to identify what factors affect the pressure and filtration in the vessels. 

Scientists believe that the development can be used to identify the causes of microcirculation disorders – this will allow predicting the dangerous consequences of the disease and improve diagnosis. The technology will allow to identify the patient’s predisposition, including to the diabetic foot syndrome.