Scientists from the Institute for the Study of Aging RNIMU them. N.I. Pirogov found differences in the activity of several genes in Russian centenarians. The press service of the university told Gazeta.Ru about this.
Scientists from the laboratory of genetics and epigenetics of aging analyzed the DNA methylation profiles obtained from tissue samples of 200 Russian centenarians – 100 women and 100 men over 90 years old. The process of DNA methylation allows the body to regulate the activity of certain genes, adjusting to the environment.
Geneticists have identified a number of candidate genes that may be specific to Russian centenarians. The PRG3 and SERPINB2 genes showed a statistically significant change in expression (activity) in all tissues studied.
Another aspect of aging, the development of chronic inflammation, is planned to be studied by biologists from the Russian National Research Medical University as part of the RussAge project. Scientists from the Laboratory of Immunology of Aging of the Russian National Research Medical University compared the state of immunity of 250 centenarians who are under observation at the Russian Gerontological Research and Clinical Center of the Russian National Research Medical University. N.I. Pirogov. It turned out that only 10% of patients had a healthy phenotype of aging and did not suffer from the syndrome of senile weakness (asthenia). In the rest of the subjects, pathological aging was observed, and the levels of inflammation biomarkers were increased by 10-20 times.
Also, the Institute staff is working on the study of plant aging and age-related changes in the human extracellular matrix (ECM), the properties of which determine the mechanical and biochemical characteristics of tissues and organs.